lrp c766t polymorphism in iranian patients with late-onset alzheimer's disease
نویسندگان
چکیده
objective: low density lipo-protein receptor- related protein (lrp) is the most important cholesterol receptor in neurons. it serves as a receptor for apoe protein which is the most important risk factor for alzheimer’s disease. lrp also contributes to the ligation of lipoproteins with apoe in neurons. association between lrp c766t and alzheimer’s disease in iranian patients with late onset alzheimer’s disease (load) was investigated in this research. materials and methods: 100 patients with load were selected based on dsm-iv-tr and nincds-adrda diagnostic criteria and 100 normal controls without any personal and family history of alzheimer’s disease or dementia were included in this case- control study. ad patients and control subjects were matched for age and sex. pcr-rflp was set up to detect lrp c766t polymorphism. results: lrp c/c genotype and c allele distribution were more frequent in ad patients than in control subjects. however, this difference was not statistically significant. when association between lrp c/c genotype and ad was categorized by the gender, in both genders, there was not any significant correlation. conclusion: our findings indicate that 766c allele of lrp gene could not significantly alter the risk of developing late-onset alzheimer's disease in iranian patients. analysis of other genetic factors and environmental factors are promoted in iranian population.
منابع مشابه
lipoprotein lipase hindiii intronic polymorphism in a subset of iranian patients with late-onset alzheimer’s disease
objective: lipid metabolism is involved in the pathogenesis of late-onset alzheimer’s disease (load). lipoprotein lipase (lpl) is a multifunctional enzyme that plays a major role in lipid metabolism; its abnormal function seems to be related, either directly or indirectly, to the pathogenesis of many diseases such as atherosclerosis, coronary artery disease (cad) and alzheimer’s disease (ad) . ...
متن کاملLipoprotein Lipase HindIII Intronic Polymorphism in a Subset of Iranian Patients with Late-Onset Alzheimer’s Disease
OBJECTIVE Lipid metabolism is involved in the pathogenesis of late-onset Alzheimer's disease (LOAD). Lipoprotein lipase (LPL) is a multifunctional enzyme that plays a major role in lipid metabolism; its abnormal function seems to be related, either directly or indirectly, to the pathogenesis of many diseases such as atherosclerosis, coronary artery disease (CAD) and Alzheimer's disease (AD) . H...
متن کاملMutational Screening in Exon 6 of the PSEN2 Gene in Iranian Patients with Late-Onset Alzheimer\'s Disease
Background and Aims: One of the most important genes involved in Alzheimer's disease (AD) is the presenilin2 (PSEN2) gene, which is one of the main constituents of the gamma-secretase complex. Mutations in this gene promote the formation of amyloid plaques resulting in AD. The study aimed to evaluate the mutation variant in exon 6 of the PSEN2 gene in patients with Late-Onset AD (LOAD). Due to ...
متن کاملassociation of calhm1 gene polymorphism with late onset alzheimer’s disease in iranian population
alzheimer's disease (ad) is a genetically heterogeneous neurodegenerative disease and late-onset type (load) is the most common form of dementia affecting people over 65 years old. calhm1 (p86l) encodes a transmembrane glycoprotein that controls cytosolic ca2+ concentrations and aß levels and p86l polymorphism in this gene is significantly associated with load in independent case controls in a ...
متن کاملAssociation of CALHM1 Gene Polymorphism with Late Onset Alzheimer's Disease in Iranian Population
Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disease and Late-Onset type (LOAD) is the most common form of dementia affecting people over 65 years old. CALHM1 (P86L) encodes a transmembrane glycoprotein that controls cytosolic Ca(2+) concentrations and Aβ levels and P86L polymorphism in this gene is significantly associated with LOAD in independent case controls in ...
متن کاملbone density in patients with late onset pompe disease
background pompe disease is an inherited metabolic disorder characterized by α-glycosidase deficiency, which leads to lysosomal glycogen accumulation in many different tissues. the infantile form is the most severe with a rapidly fatal outcome, while the late onset form has a greater phenotypic variability, characterized by skeletal muscle dysfunction and early respiratory involvement. bone min...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
modares journal of medical sciences: pathobiologyناشر: tarbiat modares university
ISSN 1562-9554
دوره 14
شماره 3 2011
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023